For more than a halfcentury after its initial recognition, mortality was near 100% and the etiology totally obscure. It is classified as primary or secondary due an underlying disorder and acute of six months or less in duration or chronic. Purpura trombocitopenica autoinmune caso clinico y revision. An overview of thrombotic thrombocytopenic purpura by hematology world facebook page regards. He proposed that a powerful poison with both agglutina. Purpura trombocitopenica trombotica symptoms, diagnosis and. Diagnosis and treatment of immune thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura ttp is the most extensive and dangerous intravascular platelet clumping disorder. Mar 27, 2017 quer saber mais sobre hematologia e principais doencas. Purpura trombocitopenica autoinmune caso clinico y revision bibliografica luis angel sequeira rojas s u m m a r y the itp is a blood illness, characterize by thrombocytopenic, and it variability intense level. It can produced in health people, but in children has been associated to viral infection, or bacterial infection. Clinical laboratory could simplify the task of differencial diagnosis measuring adamts enzime. Oct 11, 2017 an overview of thrombotic thrombocytopenic purpura by hematology world facebook page regards. Esta enfermedad afecta a varones y a mujeres por igual. Thrombocytopenia with a platelet count lower than 50. Thrombotic thrombocitopenic purpura is a rare disease with a morphological expression featured of many microthrombi in the terminal arterioles of several vital structures. Idiopathic thombocytopenic purpura itp is an autoimmune.
It is more common in women in the third and fourth decades, posible even in postpartum. A 52yearold woman with immune thrombocytopenic purpura diag nosed nine years ago has. For more than a halfcentury after its initial recognition, mortality was near 100%. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. The treatment of choice is corticosteroids, although the use of immunoglobulins and platelet transfusion is sometimes required. The diagnosis has always been difficult and the patients condition quickly worsens. Protocolo clinico e diretrizes terapeuticas purpura. Doenca autoimune, ou seja, o nosso corpo indevidamente produz anticorpos contra as nossas proprias plaquetas. Protocolo clinico e diretrizes terapeuticas portaria sasms n. Eperto e bases del diagstico e hematologa 4 purpura trombotica trombocitopenica y sindrome hemolitico uremico figura 1. Trombocitopenia inmunitaria mayo clinic mayo clinic. Purpura trombotica trombocitopenica ptt the oncology.
Immune thrombocytopenic purpura in adults is chronic, the woman are affected twice than man. Pulse methylprednisolone therapy for acute childhood idiopathic thrombocytopenic purpura. A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura itp from the intercontinental childhood itp study group. Idiopathic thrombocytopenic purpura represents 5% of all causes of thrombocytopenia during pregnancy.
Purpura trombotica trombocitopenica medicina clinica. Gernsheimer t, satratton j, ballem pj, slichter sj. A purpura trombocitopenica idiopatica,pti, tambem conhecida como purpura trombocitopenica imunonologica, autoimune ou isoimune, e uma doenca. Mar 30, 2016 purpura trombocitopenica inmune inmune julian criado clinica medica heep noviembre 2015 2.
The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. Assessment of uk practice for management of acute childhood idiopathic thrombocytopenic purpura against. Moschcowitz was the first to inform multiple hyaline thrombi as the primordial finding of a partial autopsy case. Purpura trombotica trombocitopenica y sindrome hemolitico uremico. Trombocitopenia inmunitaria sintomas y causas mayo clinic. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Assessment of uk practice for management of acute childhood idiopathic thrombocytopenic purpura. Purpura trombocitopenica trombotica hw transmision en vivo. Thrombocytopenic purpura is mostly responsible for episodes of mucocutaneous bleeding. Approach to the investigation and management of immune thrombocytopenic purpura in children.